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KMID : 0811719970010020161
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Korean Journal of Physiology & Pharmacology
1997 Volume.1 No. 2 p.161 ~ p.167
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Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment - A Quantitative Autoradiographic Study
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Hae-Young Park
Young-Sook Hong/Chan-Woong Park
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Abstract
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This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of 3H-dihydroalprenolol (3H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of 3H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala. Significant reductions of the binding of 3H-DHA to beta-2 AR were not found in any area of the brain. These data suggests that a selective down-regulation of beta-1 AR may be involved in the adaptive changes occurring after prolonged imipramine treatment.
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KEYWORD
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Beta adrenergic receptor, Rat brain, Autoradiography, Imipramine,
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